Including Phenotypic Causal Networks in Genome-Wide Association Studies Using Mixed Effects Structural Equation Models

Published in Frontiers in Genetics, 2018

Recommended citation: Momen Mehdi, Ayatollahi Mehrgardi Ahmad, Amiri Roudbar Mahmoud, Kranis Andreas, Mercuri Pinto Renan, Valente Bruno D., Morota Gota, Rosa Guilherme J. M., Gianola Daniel 2018.Including Phenotypic Causal Networks in Genome-Wide Association Studies Using Mixed Effects Structural Equation Models. https://github.com/Mehdimomen/Mehdimomen.github.io/files/Causal_Networks.pdf

Full text is here: **Abstract** Network based statistical models accounting for putative causal relationships among multiple phenotypes can be used to infer single-nucleotide polymorphism (SNP) effect which transmitting through a given causal path in genome-wide association studies (GWAS). In GWAS with multiple phenotypes, reconstructing underlying causal structures among traits and SNPs using a single statistical framework is essential for understanding the entirety of genotype-phenotype maps. A structural equation model (SEM) can be used for such purposes. We applied SEM to GWAS (SEM-GWAS) in chickens, taking into account putative causal relationships among breast meat (BM), body weight (BW), hen-house production (HHP), and SNPs. We assessed the performance of SEM-GWAS by comparing the model results with those obtained from traditional multi-trait association analyses (MTM-GWAS).