Posts by Collection

portfolio

publications

A predictive assessment of genetic correlations between traits in chickens using markers

Published in Genetics Selection Evolution, 2017

Our aim was to infer genetic correlations between three traits measured in broiler chickens by exploring kinship matrices based on a linear combination of measures of pedigree and marker-based relatedness. A predictive assessment was used to gauge genetic correlations.

Recommended citation: Momen M.,Mehrgardi, Mehrgardi A. A., Sheikhy A., Esmailizadeh A., Fozi M. A.,Kranis A., Valente B. D.,Rosa, Rosa G. J. M., Gianola D. (2017) A predictive assessment of genetic correlations between traits in chickens using markers https://github.com/Mehdimomen/Mehdimomen.github.io/files/Correlation.pdf

Predictive ability of genome-assisted statistical models under various forms of gene action

Published in Scientific Reports, 2018

Recent work has suggested that the performance of prediction models for complex traits may depend on the architecture of the target traits. Here we compared several prediction models with respect to their ability of predicting phenotypes under various statistical architectures of gene action.

Recommended citation: Momen M , Ayatollahi Mehrgardi A, Kranis A, Tusell L, Morota G, Rosa G J M, Gianola D. (2018). Predictive ability of genome-assisted predic-tion machines under various statistical genetic architectures.Scientific Reports.8:12309. https://github.com/Mehdimomen/Mehdimomen.github.io/files/GeneAction.pdf

Including Phenotypic Causal Networks in Genome-Wide Association Studies Using Mixed Effects Structural Equation Models

Published in Frontiers in Genetics, 2018

Network based statistical models accounting for putative causal relationships among multiple phenotypes can be used to infer single-nucleotide polymorphism (SNP) effect which transmitting through a given causal path in genome-wide association studies (GWAS). In GWAS with multiple phenotypes, reconstructing underlying causal structures among traits and SNPs using a single statistical framework is essential for understanding the entirety of genotype-phenotype maps.

Recommended citation: Momen Mehdi, Ayatollahi Mehrgardi Ahmad, Amiri Roudbar Mahmoud, Kranis Andreas, Mercuri Pinto Renan, Valente Bruno D., Morota Gota, Rosa Guilherme J. M., Gianola Daniel 2018.Including Phenotypic Causal Networks in Genome-Wide Association Studies Using Mixed Effects Structural Equation Models. https://github.com/Mehdimomen/Mehdimomen.github.io/files/Causal_Networks.pdf

Importance of genotype by environment interaction on genetic analysis of milk yield in Iranian Holstein cows using random regression model.

Published in Animal Production Science, 2018

Changes in the relative performance of genotypes (sires) across different environments, which are referred to as genotype–environment interactions, play an important role in dairy production systems, especially in countries that rely on imported genetic material. Importance of genotype by environment interaction on genetic analysis of milk yield was investigated in Holstein cows by using random regression model.

Recommended citation: Fazel Y., Esmailizadeh A., Momen M., Fozi M. Asadi (2018) Importance of genotype by environment interaction on genetic analysis of milk yield in Iranian Holstein cows using a random regression model.

Leveraging breeding values obtained from random regression models for genetic inference of longitudinal traits

Published in The Plant Genome, 2019

This study builds on the random regression genomic prediction approach described in Campbell et al 2018, and used the derived breeding values for genomic inferenece across time points.

Recommended citation: Campbell M.T., Momen M., Walia H., Morota G. (2019) Leveraging breeding values obtained from random regression models for genetic inference of longitudinal traits. The Plant Genome. https://github.com/Mehdimomen/Mehdimomen.github.io/files/RRM_1.pdf

Harnessing phenotypic networks and structural equation models to improve genome-wide association analysis

Published in BioRxiv, 2019

We extended the scope of MTM-GWAS by incorporating phenotypic network structures into GWAS using structural equation models (SEM-GWAS). In this network GWAS model, one or more phenotypes appear in the equations for other phenotypes as explanatory variables. A salient feature of SEM-GWAS is that it can partition the total single nucleotide polymorphism (SNP) effects into direct and indirect effects.

Recommended citation: Momen, Mehdi and Campbell, Malachy T. and Walia, Harkamal and Morota, Gota. 2019. Harnessing phenotypic networks and structural equation models to improve genome-wide association analysis.bioRxiv. https://github.com/Mehdimomen/Mehdimomen.github.io/files/BN_SEM_GWAS.pdf

talks

teaching

Teaching experience 1

Undergraduate course, University 1, Department, 2014

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Teaching experience 2

Workshop, University 1, Department, 2015

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