Harnessing phenotypic networks and structural equation models to improve genome-wide association analysis
Published in BioRxiv, 2019
We extended the scope of MTM-GWAS by incorporating phenotypic network structures into GWAS using structural equation models (SEM-GWAS). In this network GWAS model, one or more phenotypes appear in the equations for other phenotypes as explanatory variables. A salient feature of SEM-GWAS is that it can partition the total single nucleotide polymorphism (SNP) effects into direct and indirect effects.
Recommended citation: Momen, Mehdi and Campbell, Malachy T. and Walia, Harkamal and Morota, Gota. 2019. Harnessing phenotypic networks and structural equation models to improve genome-wide association analysis.bioRxiv. https://github.com/Mehdimomen/Mehdimomen.github.io/files/BN_SEM_GWAS.pdf